Project area A: Cell biology of megakaryocytes and platelets
- A01 – Mechanisms of megakaryocyte polarisation and platelet biogenesis
- A02 – Casein kinase-dependent signalling in platelet activation and thrombopoiesis
- A03 – Impact of the irradiated bone marrow niche on platelet biogenesis
- A04 – Optogenetic approaches to study platelet production
- A05 – A new role of cGMP in platelet mechanotransduction
- A06 – The role of the platelet cytoskeleton in platelet mechanics
- A07 – Mechanisms of platelet receptor regulation and disintegration
- A08 – Regulation of the platelet lipidome and its implications in thrombo-inflammation
- A09 – Relevance and molecular mechanisms of zinc homeostasis in megakaryo-poiesis and platelet function
- A11 – The interplay between platelets and pathogenic bacteria
Project area B: Platelets as regulators and effectors in disease
- B01 – Platelet-dependent inflammation and functional recovery of ischaemic myocardium and brain
- B02 – Platelet-dependent injury and safeguard mechanisms in acute ischaemic stroke
- B03 – Platelet CypA/RAGE as modulators of inflammation and immune responses during myocardial remodelling
- B04 – Role of platelets in tissue remodelling and functional recovery after experimental cerebral ischemia
- B05 – Role of platelets for initiation, progression and maintenance of cholangiocarcinoma metastasis
- B06 – Platelets as modulators of neuro-inflammation in the ischaemic brain
- B07 – Mechanisms of platelet-dependent pulmonary inflammation in the Acute Respiratory Distress Syndrome (ARDS)
- B08 – Platelets in resolution of liver inflammation and tissue regeneration
- B09 – Platelet-derived inflammatory mediators in degenerative aortic valve disease and subclinical endocarditis
- B10 – The impact of platelets on the maintenance of pancreatic β cell mass and development of diabetes
Central projects and INF
- INF – The Virtual Platelet Platform ViPP: An Images and Systems Biology data repository and workbench
- Z02 – Analysing signalling molecules and modifications in platelets by proteomics, lipidomics and bioinformatics
- Z03 – Translational platform
- Z04 – Multiparametric in vivo imaging