Principal Investigator

Prof. Dr. Bernhard Nieswandt

Professor (W3) and Chair of Experimental Biomedicine I

Bernhard Nieswandt studied biology and biochemistry in Regensburg and Canterbury (UK). From the beginning of his studies, his focus was already on platelets and inflammation, an entirely new research field at this time, and he developed the world’s first antibodies against mouse platelet receptors, which became important tools in the study of these cells.
After his habilitation in experimental medicine, completed at the University of Witten/Herdecke, a prestigious Heisenberg-Fellowship, awarded by the DFG in 2002, allowed him to pursue his basic scientific research at the University of Würzburg, where he has been advancing cardiovascular and neurovascular research with groundbreaking discoveries ever since. He was the first to establish a research group in the newly founded Rudolf Virchow Center, University of Würzburg, and was appointed head of the Chair of Experimental Biomedicine I in 2008. He was coordinator and spokesperson of two DFG-funded research consortia: CRC 688 “Cardiovascular cell-cell interactions” and CRC/TR240 “Platelets”.
With his team, he has laid the foundation for two medications: a Factor XIIa inhibitor from CSL Behring and GPVI inhibitors, which have just entered clinical phase III studies. He has published over 320 papers, cited more than 26,000 times.
In April 2024, Bernhard Nieswandt received a prestigious ERC Advanced Grant for his groundbreaking research.

Institute of Experimental Biomedicine – Chair I
University Hospital and Rudolf Virchow Center
University of Würzburg

Josef-Schneider-Str. 2 / D15
97080 Würzburg
Germany

Email: bernhard.nieswandt@uni-wuerzburg.de
https://www.platelets.eu/

Team

Bonfiglio, Sabrina Ivana

Ph.D. student

Sabrina obtained a Bachelor’s degree in Biology and a Master’s degree in Molecular Biology and Genetics from the University of Pavia. In April 2024, she started her PhD in the Nieswandt Lab at the Rudolf Virchow Center in Würzburg. As part of the ERC-funded PITT-Inflame project, her research focuses on unraveling the role of Platelet-derived Integrin and Tetraspanin-enriched Tethers (PITTs) and their pathophysiological significance in thrombo-inflammatory processes. She employs genetic and pharmacological approaches to interfere with PITT formation and effector mechanisms in thrombo-inflammatory disease models, aiming to uncover novel therapeutic targets.

Institute of Experimental Biomedicine I
University Hospital and Rudolf Virchow Center Würzburg
University of Würzburg
Josef-Schneider-Straße 2

97080 Würzburg
Germany

Phone: +49 931 31-99813
Email: Bonfiglio_S@ukw.de

Dr. Cuenca Zamora, Ernesto José

Postdoc

Ernesto is a biochemist with a PhD in Integration and Modulation of Signals in Biomedicine from the University of Murcia, supported by a competitive FPU-MECD contract (2019-2023). During his doctoral training, with a research stay at the University of Tromsø (Norway) with Dr. Arranz, he investigated the role of inflammation in the progression of myeloproliferative neoplasms, specifically to myelofibrosis. His work resulted in publications as co-first author in Cell Rep Med (2023) and first-author in Am J Hematol and Biomed Pharmaco (2024). Currently, as part of the ERC-funded PITT-Inflame project, he is focusing on deciphering the role of PITTs in modulating immune cell interactions, with the aim of uncovering potential therapeutic targets for thrombo-inflammatory diseases.

Institute of Experimental Biomedicine I
University Hospital and Rudolf Virchow Center Würzburg
University of Würzburg
Josef-Schneider-Straße 2

97080 Würzburg
Germany

Phone: +49 931 31-88898
Email: CuencaZamo_E@ukw.de

Dr. Onursal Karakoc, Ceylan

Postdoc

Ceylan Onursal is a pharmacist with a PhD in Medical Research from Ludwig Maximilian University Munich. She specialized in Lung Biology and Disease at Helmholtz Zentrum München’s Institute of Lung Health and Immunity. During her doctoral research with Associate Professor Dr. Claudia Staab-Weijnitz, she investigated the role of Prolyl-3-hydroxylase 4 (P3H4) in collagen synthesis and secretion in lung fibroblasts, identifying its potential as a drug target for pulmonary fibrosis. Currently, she is a postdoctoral researcher at the Rudolf Virchow Center, working on the ERC-funded PITT-Inflame project. Her research focuses on the molecular composition and regulation of Platelet-derived Integrin and Tetraspanin-enriched Tethers (PITTs) and their interactions with endothelial and immune cells to uncover novel therapeutic targets for thrombo-inflammatory diseases.

Institute of Experimental Biomedicine I
University Hospital and Rudolf Virchow Center Würzburg
University of Würzburg
Josef-Schneider-Straße 2
97080 Würzburg
Germany

Building: D15
Room: 02.010

Phone: +49 931 31-99813
Email: Onursal_C@ukw.de

Siegmann, Kerstin

Assistant

Kerstin Siegmann is a trained foreign language correspondent and worked for several years as a secretary in a non-profit organization. She gained further professional experience as a management assistant in the IT-industry and in the purchasing department of a diagnostics company before she joined the Chair of Experimental Biomedicine I in 2014 as office assistant. She provides administrative support to the institute management, focusing on externally funded research projects.

University Hospital Würzburg
Josef-Schneider-Str. 2, Building D15
97080 Würzburg
Germany

Phone: +49 931-31 81457
Email: siegmann_k@ukw.de

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